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In mouse and human squamous cell carcinoma, loss of function of FAT1 promotes tumour initiation, malignant progression and metastasis through the activation of a hybrid epithelial-to-mesenchymal transition phenotype.
A many-atom state of trapped 171Yb atoms that are entangled on an optical atomic-clock transition overcomes the standard quantum limit, providing a proof-of-principle demonstration towards entanglement-based optical atomic clocks.
Multilayer 3D reconstitution of bladder stem cells with stromal cells enables recapitulation of the architecture and molecular functions of bladder tissue.
An anion and metal ion template is used to form woven polymer patches that are joined together by polymerization into a fully woven, two-dimensional, molecular patchwork.
The number of edge channels in quantum anomalous Hall insulators is controlled by varying either the magnetic dopant concentration or the interior spacer layer thickness, yielding Chern numbers up to 5.
Live neuron imaging and electron microscopy reconstruction shows that the selectivity of cortical neuron responses to visual stimuli arises from the total number of synapses activated rather than being dominated by a small number of strong synaptic inputs.
A tweezer clock containing about 150 88Sr atoms achieves trapping and optical excited-state lifetimes exceeding 40 seconds, and shows relative fractional frequency stability similar to that of leading atomic clocks.
Genome-wide siRNA screens identify an essential function for sorting nexin 5 in virus-induced autophagy and immunity mediated via class III phosphatidylinositol-3-kinase complex 1.
Cryo-electron microscopy structures of non-structural protein 1 (nsP1) of chikungunya virus reveal the mechanisms that underpin the association of viral replication machinery with virus-induced membranous organelles within host cells.
Tryptophan depletion in melanoma cells after prolonged treatment with interferon-γ (IFNγ) results in ribosomal frameshifting and the production of aberrant peptides that can be presented to T cells and induce an immune response.
Analysis of US continental wetland inventory data combined with model simulations indicate that a spatially targeted 10% increase in wetland area could double wetland nitrogen removal.
A van der Waals structure based on a two-dimensional magnet and layered superconductor offers a potential system in which topological superconductivity could be easily tuned and integrated into devices.
Validated barrier inventories and modelling indicate that Europe’s rivers are fragmented by more than one million barriers, such as dams, weirs and fords, causing major impacts on biodiversity.
Spin transport far from equilibrium is studied in a Heisenberg model with adjustable anisotropy realized with coupled ultracold 7Li atoms, and different dynamical regimes are found for positive and negative anisotropies.
A high-throughput, chromosome-wide analysis of DNA looping reveals its contribution to the organization of chromatin, and provides insight into how nucleosomes are deposited and organised de novo.
Strong electron–electron interactions in magic-angle twisted bilayer graphene can fundamentally change the topology of the system’s flat bands, producing a hierarchy of strongly correlated topological insulators in modest magnetic fields.
A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.
Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the roles of FOS and SCG2 in neural plasticity and consolidation of memories.
