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α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.
Magma storage and differentiation in the Earth’s crust mainly occurs by reactive melt flow in long-lived mush reservoirs, rather than by fractional crystallization in magma chambers, as previously thought.
A modelling framework is presented to determine the optimal layout and physical properties of networks in which the nodes and links have physical sizes and intersections between components is prohibited.
A refractive lens and a refractive prism for extreme-ultraviolet radiation have been developed that use the deflection of the radiation in an inhomogeneous jet of atoms.
Stella, a factor essential for female fertility, protects the oocyte methylome in mice by suppressing de novo DNA methylation mediated by the DNA methyltransferase DNMT1.
Improved techniques allow the measurement of a frequency difference with an uncertainty of the order of 10–19 between two independent atomic optical lattice clocks, suggesting that they may be able to improve state-of-the-art geodetic techniques.
Single-cell analysis reveals that interactions with the extracellular matrix via integrin α5 and mechanotransducer YAP1 determine whether pancreatic progenitors develop along the duct or endocrine lineages.
High-angular-resolution observations of the quasar 3C 273 reveal that it has a relatively small but thick disk, viewed nearly face-on, in which material is orbiting the central supermassive black hole.
In mammalian cells, NP220 is a key protein that recruits the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 to silence unintegrated retroviral DNA.
The position of the Southern Hemisphere westerly winds responds immediately to abrupt North Atlantic climate events of the last ice age, with a spatially heterogeneous impact on Antarctic climate.
An in vitro system that generates three-dimensional cultures of extraembryonic fetal trophoblast cells that differentiate into the two main types of trophoblast can be used to study human placental development.
The kinase CDK12 suppresses usage of intronic polyadenylation sites and thereby promotes the expression of genes involved in homologous recombination DNA repair.
PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.
Using a double-aberration-corrected transmission electron microscope, intercalation of lithium between two graphene sheets is found to produce a dense, multilayer lithium phase, rather than the expected single layer.
A non-classical superposition of zero- and one-phonon mechanical Fock states is generated and measured by strongly coupling a surface acoustic-wave resonator to a superconducting qubit.
Climate-driven periodicity of flowstone accretion between 3.2 and 1.3 million years ago in Cradle of Humankind caves reveals that the presence of hominin fossils reflects accumulation in open caves during intermittent, substantially drier phases.
Circuit quantum acoustodynamics is used to achieve controlled generation of multi-phonon Fock states in a bulk acoustic-wave resonator, which are demonstrated to have a quantum nature.