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In the early embryo, Cas9 expressed in the female germline induces double-stranded breaks that are corrected by homology-directed repair, biasing inheritance of a desired allele in mice.
The thermal vibrations of a carbon nanotube are directly measured in real time with high displacement sensitivity and fine time resolution, revealing dynamics undetected by previous time-averaged measurements.
A genetic study of the baseline human antibody repertoire, based on the circulating B cell populations of ten subjects, reveals universally shared antibody clonotypes within repertoires that are largely unique to the individual.
Photoredox transformations are achieved with infrared light by using triplet fusion upconversion that converts infrared into visible light, enabling the use of photoredox chemistry on larger scales and through barriers that are impenetrable by visible light.
A magnetic contribution to the spin Hall effect is observed in the non-collinear antiferromagnet Mn3Sn, which is attributed to momentum-dependent spin splitting produced by non-collinear magnetic order.
Distinct but partially overlapping subsets of neurons in the orbitofrontal cortex of mice respond to feeding and/or social stimuli and, when optogenetically stimulated at single-cell resolution, specifically regulate reward-seeking behaviours.
Quantitative explorations using biomechanics and robotics of the gait of Orobates, a stem amniote, indicate that the development of relatively erect, power-saving and balanced locomotion preceded the diversification of crown amniotes
Increased glutamine metabolism caused by unregulated HIF-1α signalling in mouse chondrocytes results in increased post-translational modification of collagen and skeletal dysplasia, demonstrating that strict regulation of HIF-1α signalling in chondrocytes is essential for normal bone growth.
A kiwellin protein in maize is found to inhibit the activity of the secreted enzyme chorismate mutase from a maize-infecting pathogenic fungus, suggesting a role for kiwellins in plant immunity.
Multi-epoch observations of a supernova associated with a γ-ray burst reveal spectral features at extremely high expansion velocities within the first day after the burst, indicative of a choked jet.
Organoids derived from human stem cells recapitulate the structure and functions of human blood vessels, and can be used to model and identify regulators of diabetic vasculopathy.
Cell-labelling experiments are used to demonstrate that the hindgut in the chick embryo is formed by cells moving through the stationary caudal intestinal portal as a result of a contractile force gradient directed by fibroblast growth factor signalling.
A ferroelectric thin film that behaves as a single domain is found to exhibit both negative capacitance and the predicted double-well polarization–energy relationship.
Photometry and parallax data from the Gaia satellite provide direct observational evidence of a theoretically predicted pile-up in the cooling sequence of white dwarfs, which is associated with core crystallization.
Radial growth in the roots of Arabidopsis, which is mediated by gene expression activated by the mobile PEAR1 and PEAR2 transcription factors, is initiated around protophloem-sieve-element cell files of procambial tissue.
Specific ablation of mitochondrial complex III subunits in Treg cells in mice results in inflammatory disease, altered Treg gene expression and defective Treg function, indicating a key functional role for mitochondrial complex III in Treg cells.