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Tilg et al. explore how metabolic dysfunction, altered gut microbiome and dysregulated innate and adaptive immunity contribute to NAFLD and how the interplay between these factors mediates disease progression.
Zechner and colleagues discuss mechanisms facilitating the mobilization of intracellular fatty acids and how they affect lipid-mediated signalling, metabolic regulation and energy homeostasis in health and disease.
Wiley and Campisi discuss metabolic inducers of senescence and alterations in cellular metabolism associated with senescence, while pointing out interventions that target metabolic processes to mitigate senescence.
Adipose tissue has emerged as a highly heterogeneous organ. Sun et al. discuss the heterogeneity of thermogenic adipocytes and their precursors, highlighting the single-cell technologies that help to characterize adipose tissues in depth.
Schwartz et al. review mechanisms through which the central nervous system achieves metabolic homeostasis in the basal and postprandial states, and how dysfunction of this integrated central fuel homeostasis control system can contribute to metabolic disease.
Evers et al. explore the interconnection between cellular mechanics and metabolism, emerging paradigms and the role of this interaction in cancer, cardiovascular disease and fibrosis.
Cancer cells undergo metabolic rewiring to support unrestrained proliferation, but dependence on oncogenesis-supportive metabolites could be leveraged therapeutically. Geeraerts et al. explore the centrality of serine and glycine metabolism to cancer survival, and how targeting the de novo serine and glycine synthesis pathways can complement current therapies.
The tumour microenvironment (TME) is a unique cellular and metabolic landscape. Elia and Haigis describe how metabolism influences, and is affected by, the complexity of cellular interactions within the TME and highlight opportunities for therapeutic intervention.
