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Arrays of ultrasonic transducers arranged hemispherically around the head enable the mapping of haemodynamic changes in the brain via photoacoustic computed tomography at resolutions down to 350 micrometres and 2 seconds.
Volumetric histological imaging of mouse and human tissues without the need for tissue staining or excision can be performed in real time via microscopes leveraging confocally aligned light-sheet illumination.
This Perspective highlights notable milestones from the past two decades of research in cardiac tissue engineering, and outlines opportunities and challenges for further advancement.
Deep-learning models trained with images of the external part of the eyes, rather than fundus images of the retina, can also be used to detect severe diabetic conditions, such as diabetic retinopathy.
Ultrasound pulses have been used to modulate a liver–brain autonomic nerve pathway to prevent or reverse the onset of hyperglycaemia in models of diabetes in several species. The ion channel TRPA1 was shown to be essential in transducing the ultrasound stimuli within the metabolic control circuit.
Freeze-dried genetic circuits can be integrated with textiles for the detection — colorimetric, or via fluorescence or luminescence — of small molecules and nucleic acids from SARS-CoV-2 and other pathogens.
A method connecting single-cell genomic, transcriptomic or proteomic profiles to functional cellular characteristics, especially time-varying phenotypic changes, would inform our understanding of cancer biology. We present functional single-cell sequencing (FUNseq) to address this need and describe how it might provide a unique way to unravel mechanisms that drive cancer.
Off-target genome editing in the liver can be reduced by using lipid nanoparticles to deliver oligonucleotides that disrupt the secondary structure of single-guide RNAs as well as short interfering RNAs targeting Cas9 mRNA.
An electromechanical chip consisting of self-assembled DNA-based cantilevers immobilized on a liquid-gated graphene field-effect transistor can be configured to rapidly detect ultra-low concentrations of biomolecules, including viral nucleic acids, in biological fluids.
This Review discusses the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal degeneration, as well as upcoming technologies for enhancing vision restoration.
This Review discusses the challenges and opportunities, biological and technical, of technologies for the analysis of cell-free DNA for the diagnosis of cancer.
Coating mesenchymal stromal cells with a soft gel incorporating specific chemomechanical cues that enhance the production of collagenases enhances the ability of the cells to inhibit aberrant tissue remodelling in mice with fibrotic lungs.
Flagellated bacteria coated with antigen-adsorbing nanoparticles and injected into irradiated tumours elicit systemic antitumour immune responses by transporting tumour antigens towards the tumour periphery, where they are taken up by functional antigen-presenting cells.
The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.
This Perspective describes the ecosystem of software available for the analysis of tissue images and discusses the need for interactive online guides that help histopathologists make complex images understandable to non-specialists.
This Perspective describes current clinical standards for intraoperative tissue analysis in oncology and discusses potential clinical implementations of intraoperative imaging for pathology-assisted surgery.
Deep surgical wounds can be monitored via conductive multifilament surgical sutures incorporating ‘sensing pledgets’ bearing capacitive sensors operated via harmonic radiofrequency identification.
