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Nanoscale extracellular vesicles can be efficiently isolated in about 15 minutes, for downstream analyses of nucleic acids and proteins, via spontaneous labelling through a lipid nanoprobe and subsequent magnetic capture of the labelled vesicles.
A macromolecular near-infrared probe that successively responds to tumour acidity and hypoxia while amplifying detection sensitivity via signal propagation detects metastatic tumour nodules as small as 1 mm in mice.
A peptide-based fluorescent inhibitor of the dimerization of an oncoprotein of the Epstein–Barr virus blocks the proliferation of tumours associated with the virus in mice.
A carbon nanotube sensor enables real-time optical quantification of hybridization events of microRNA and other oligonucleotides in vivo and in whole urine and serum.
A hydrogel made of crosslinked clusters of highly branched polymers that has ultralow swelling pressure and that forms in 10 minutes despite its low polymer content functions as an artificial vitreous body for over one year without inducing adverse effects.
Rapid DNA expression in millions of cells per minute can be achieved with a microfluidic device that integrates mechanical squeezing of the cells and electric-field-mediated transient disruption of the plasma and nuclear membranes.
An extracorporeal cross-circulation approach enables, in a swine model, 36 hours of normothermic perfusion in healthy lungs, the recovery of injured lungs, and extended therapeutic interventions in all lungs.
A phased electromagnetic surface that conforms to the body surface can regulate cardiac rhythm in a porcine model through the wireless transmission of power to miniaturized semiconductor devices implanted at depths of over 4 cm.
Capacitive coupling between tissue and flexible integrated electronics through a sealing dielectric layer facilitates long-term electrophysiology measurements, as demonstrated in ex vivo Langendorff heart models.
A scanning fibre endoscope, combining reflectance and laser-induced fluorescence emission of intrinsic fluorescent constituents in vascular tissue, provides real-time structural, biochemical and biological images of human atherosclerotic plaques.
A light-scattering method implemented by using fibre-optic technology that can be directly incorporated into standard vascular-access devices allows for real-time monitoring of blood coagulability in the operating room.
A rapid, inexpensive and ultrasensitive assay that uses antibody-conjugated nanoparticle probes on the surface of a sensor chip quantifies tumour-derived extracellular vesicles to detect pancreatic cancer from 1 μl of blood plasma.
A man/machine interface based on the activity of spinal motor neurons reinnervating the muscles of a missing limb in amputees enables the generation of neural signals for potential prosthetic control.
By taking advantage of stimulated Raman spectroscopy and fibre-laser technology, virtual histology images can be obtained in real time in the operating room, with diagnostic quality comparable with that achieved via conventional histopathology.
A biocompatible, energy-harvesting electrochemical cell delivers power to a wireless sensor for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs.
An artificial intelligence agent integrated with a cloud-based platform for multihospital collaboration performs equally as well as ophthalmologists in the diagnosis of congenital cataracts in a series of online tests and a multihospital clinical trial.
By targeting the surgical bed and circulating tumour cells, platelets conjugated with an antibody against an immune checkpoint protein prevent tumour recurrence and metastasis following resection of the primary tumour.
A hand-powered centrifuge made of two paper discs, string and wooden handles is shown to achieve rotational speeds of 125,000 r.p.m., separate pure plasma from whole blood in less than 1.5 minutes and isolate malaria parasites in 15 minutes.
A fluorescent nanoprobe that amplifies the fluorescent signal in a broad range of tumours allows for real-time tumour-acidosis-guided detection and surgery of occult, less-than-1-mm3 nodules in mice bearing head and neck or breast tumours.