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A biodegradable probe made of dextran and a urea-based targeting ligand for prostate-specific membrane antigen enables targeted magnetic resonance imaging of tumours expressing the receptor in a xenograft mouse model of prostate cancer.
A computational approach that uses the statistics of movement to find a mapping between neural activity and motor variables decodes the intended movements of monkeys with performance comparable to that of supervised methods.
A slide-free, inexpensive and non-destructive microscopy technique rapidly provides high-resolution histology images that resemble those obtained from conventional haematoxylin-and-eosin-stained specimens.
An injectable hyaluronic acid hydrogel for the sustained delivery of miR-302 mimics to the heart promotes cardiomyocyte proliferation and improves cardiac function in mice after myocardial infarction.
A model accounting for the properties of the local chromatin environment predicts the modulation of patterns in gene expression and helps screen for chemotherapeutic adjuvants that lead to an enhanced therapeutic response in cancer cells.
An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.
A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer’s disease or amyotrophic lateral sclerosis..
An implantable device consisting of a biodegradable core and a tubular braided sleeve autonomously elongates to accommodate tissue growth, as shown with prototypes implanted on a rat tibial bone and a piglet heart valve.
The expression of two specific DNA-repair factors promotes homology-directed repair and enhances the precision of CRISPR–Cas9 gene editing at multiple loci in human cells, including patient-derived induced pluripotent stem cells.
Epigenetic and transcriptomic differences in human induced pluripotent stem cells generated from the same fibroblast population reveals that the reprogramming method affects the cells’ gene-expression levels but not their differentiation potential.
A method that identifies patterns of tumour heterogeneity in intact biopsy samples using 3D light-sheet microscopy stratifies patients by tumour stage.
Gold nanoparticles carrying Cas9 ribonucleoprotein and donor DNA, and complexed with endosomal disruptive polymers, correct the DNA mutation that causes Duchenne muscular dystrophy in mice, with minimal off-target effects.
The location of microdevices in the body of anaesthetized mice can be retrieved with sub-millimetre precision by adopting principles from nuclear magnetic resonance.
Nanoscale vibrations provided by a bioreactor induce the differentiation of mesenchymal stem cells into mineralized tissue in three dimensions, independently of other environmental factors.
A dendrimer that depletes bioavailable copper and leads to the suppression of tumour angiogenesis acts as a potent and non-cytotoxic anticancer therapeutic.
A scanning laser-emission-based microscope enables submicrometre-resolution mapping of nuclear biomarkers and the diagnosis of early-stage lung cancer in tissue samples from patients.
A general technique that overcomes the temperature sensitivity of existing polymerase-chain-reaction methods selectively amplifies single-nucleotide DNA variants.
Ultrasound pulses controlling the release of an anaesthetic encapsulated in liposomes allow for the timing, intensity and duration of sciatic-nerve blocks in rats.