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In this Perspective, the authors discuss experimental scenarios that breach the assumption of independence of all samples or participants in a study, specifically in aging research. They outline various strategies to improve the rigor and accuracy of the science with design and analysis solutions, while also considering real-world constraints.
This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.
In this Perspective, Jan Vijg and Brandon Milholland discuss that at high ages the probability of survival becomes vanishingly small, presenting a soft limit to human lifespan. They elaborate on the mechanistic basis of the observed limit to maximum human lifespan, and on the seemingly impossible future developments required to circumvent the current limit.
Carol Brayne and Terrie Moffit discuss the limitations of large-scale volunteer databanks (LSVD) for understanding aging and disease, call for further evaluation of their value and offer their thoughts on how to make the reporting of LSVD studies more transparent.
This Perspective describes the blueprint, challenges and potential solutions for the transformation of Alzheimer’s disease clinical care pathway with biomarker-guided and digitally facilitated detection and intervention at early disease stages.
The authors discuss how adopting a complex systems perspective is a crucial step in advancing our understanding of the aging process and requires fundamental alteration of the questions being asked and the methods used to answer them.
Whether and how cognitive training may be used to improve cognitive functions in older age remains incompletely explored, and existing studies have yielded inconsistent results. Here, the authors argue that emerging technologies can transform the field of cognitive enhancement by enabling personalized strategies for cognitive enhancement in older adults.
Suicide is an important problem among older adults and in particular older men. Here, the author discusses factors that impact suicide risk, including social determinants of health and cultural perception of old age, and proposes strategies for a multifaceted approach to suicide prevention.
