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Studies have identified sex and/or gender differences in Alzheimer’s disease, but few have examined other dementias. We highlight sex and gender differences in other dementias, discuss sociocultural factors and provide a framework for future global studies.
Rapid progress in the development of novel biomarkers and lifestyle interventions and the emergence of the first disease-modifying therapy have revolutionized our approach to dementia diagnosis, prevention and therapy. In this Focus issue, Nature Aging presents a collection of reviews and opinion pieces on recent advances in dementia research.
The World Health Organization (WHO) blueprint for dementia research provides a roadmap to addressing the challenges in the field and reshaping our approach to dementia research. This Comment focuses on how to operationalize the drivers of research highlighted in the blueprint to make research more equitable, impactful and global.
A major transformation in dementia diagnosis and care appears imminent and will depend on three major types of biomarkers: molecular imaging, blood-based biomarkers and cerebrospinal fluid biomarkers. Each modality has unique strengths and limitations that suggest its optimal uses in research, clinical trials and clinical diagnosis.
The Global Council on Brain Health summarizes disparities that occur among the opportunities of different groups for adopting and sustaining brain-healthy behaviors across the lifespan. Here, we highlight challenges for people to maintain a healthy mind throughout their lives and suggest solutions for society to help people to achieve greater equity in brain health.