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  • Collection |

    Neoplastic diseases of the pancreas and the biliary tract share numerous common features regarding their morphology, immunohistochemical profile and molecular driver events. In the last few years, numerous efforts have been made towards standardization of the diagnostic approach to these malignancies and exploration of their biologically relevant pathomechanisms, such as the interaction with the microenvironment. In addition, the integration of immunophenotypical and molecular data into the classical histomorphological approach has led to the definition of new entities and to a clear-cut and more clinically relevant classification of the already known ones. In this virtual issue we highlight papers from Modern Pathology and Virchows Archiv which deal with the most recent developments in molecular pathogenesis, classification, and diagnosis of pancreatobiliary neoplasms.

    Image: Pai RK & Pai RK (2018) Pathologic assessment of gastrointestinal tract and pancreatic carcinoma aftre neoadjuvant therapy. Mod Pathol 4-23

  • Focus |

    Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. The pathological spectrum of NAFLD ranges from simple steatosis to the necro-inflammatory and fibro-progressive form, non-alcoholic steatohepatitis (NASH), which may then progress to cirrhosis, liver failure and hepatocellular carcinoma. This web focus features papers from Laboratory Investigation and Modern Pathology that present new models and techniques, diagnostic advances, mechanistic insights and potential innovative therapies for NAFLD and NASH. Photo credit: Ming-Hong Tai

  • Collection |

    The editors of Laboratory Investigation and Modern Pathology present a variety of recent papers related to ocular pathology. These experimental and diagnostic studies cover congenital anomalies, corneal injury and repair, degenerative disease, and various malignancies.

    Image: Peter Lwigale

  • Collection |

    The editors of Modern Pathology present a collection of innovative papers from European authors. The studies describe novel uses of image analysis, potential new biomarkers, and advances in molecular pathology.

    Image: W Glenn McCluggage

  • Supplement |

    In this era of minimally-invasive procedures for diagnosis, prognosis and treatment decisions, pathologists are asked to make more specific diagnoses from smaller samples. We asked top experts in their fields to discuss their strategies and most practical approaches to maximizing the information gained from limited specimens.

    Image: Kaminsky Productions

  • Focus |

    The editors of Modern Pathology are pleased to present a selection of recent papers that focus on the diagnosis of gastrointestinal cancers from top international researchers in anatomic and molecular pathology. We present studies on prognostic markers of colorectal cancer and classification of gastric carcinoma, as well as research on the pathobiology of less common conditions such as colorectal mixed adenoneuroendocrine carcinoma, small intestinal adenocarcinoma and gastroblastoma.

  • Supplement |

    The United States & Canadian Academy of Pathology annual meeting was held at the Henry B.

    Image: Neurons: ingimage; head: created in-house