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This cover image shows a histologic section of the urinary bladder that was stained with DAPI (blue), Epcam-1 (white) and F4/80 (red). The image indicates the dense network of macrophages in the lamina propria. Upon infections with uropathogenic E.coli, these macrophages migrate towards the infection to fight off the infection. Image courtesy of Jenny Bottek, Julia Volke and Daniel R. Engel, Department of Immunodynamics, University Duisburg-Essen, Germany. For further information please see article in this issue, page 702.