Cover Credit: Brain cortical slices from intracerebroventricular (ICV)-injected Neu1 -/- mice were subjected to immunofluorescence staining for NEU1 (red), Iba1 (green), and DAPI (blue). Expression of NEU1 was restored, including in the perikaryon of microglia (arrows). The morphology of microglia was also normalized.

Cover Credit: AAV-mediated gene therapy for hereditary hearing loss is transitioning from basic research to clinical application. The biodistribution of different AAV vectors after inner ear injection is crucial for researchers to select appropriate serotypes with targeted capabilities while decreasing non-target expression. The image shows the brain transduction of AAV1, AAV2, Anc80L65, AAV9, AAV-PHP.B, and AAV-PHP.eB after round window membrane (RWM) delivery at neonatal mice.

Cover Credit: Alfred Pasieka/Science Photo Library