Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Kurtovic et al. highlight some of the recent advances in the development and clinical evaluation of malaria vaccines. The authors outline key vaccine strategies and clinical trials, and discuss priorities for research into the development of an efficacious malaria vaccine.
Vokinger et al. discuss potential sources of bias in machine learning systems used in medicine. The authors propose solutions to mitigate bias across the different stages of model development, from data collection and preparation to model evaluation and application.
KRAS is one of the most commonly mutated oncogenes in lung cancer but has long been considered undruggable. With the recent FDA approval of sotorasib, supported by positive phase II trial data now published in The New England Journal of Medicine, this is no longer the case.
Dengue virus is transmitted by Aedes aegypti mosquitoes and causes the disease known as dengue. In a trial published in The New England Journal of Medicine, Utarini and colleagues report that release of wolbachia-infected A. aegypti populations in a dengue endemic area reduces the number of symptomatic cases and of hospitalisations.
Alwan discusses the lessons learnt over the past year regarding Long COVID, prolonged illness resulting from SARS-CoV-2 infection, and their implications for public health policy and disease management, drawing insight form her own lived experience, research, and advocacy work with Long COVID.
Lazarus et al. outline the barriers slowing down the COVID-19 vaccination campaign in Spain. They issue a call to action for all stakeholders to improve access to vaccines, with a particular emphasis on reaching marginalised populations.
Kundu discusses how artificial intelligence will transform medical practice and doctors’ training. The author explores the changing role of the clinician in the doctor-patient relationship, drawing parallels with the role of the pilot in light of increased automation in aviation.
Amyloid-β peptide (Aβ) deposition in the brain is an early feature of Alzheimers’ disease. In a phase II clinical trial recently published in The New England Journal of Medicine, Mintun and colleagues report on the safety and efficacy of an antibody targeting Aβ peptide in amyloid plaques for the treatment of participants with early symptomatic Alzheimer’s disease.
Communications Medicine is publishing its first articles today. We are an inclusive and open access medical journal that aims to facilitate and disseminate discovery that will promote health for all and improve the lives of those experiencing or living with disease.
In patients with high cholesterol and at risk of cardiovascular disease, inhibitors of PCSK9 are useful in lowering lipid levels but must be dosed regularly. A recent study in Nature by Munsunuru and colleagues explores the possibility of permanently disrupting PCSK9 expression via in vivo CRISPR gene editing in non-human primates, with long-lasting reductions in LDL cholesterol.
Kurtzhals et al. mark the centenary of the discovery of insulin by looking back at how this model protein has changed science and medicine. They discuss how lessons learned from insulin over the last one hundred years are shaping the present and future of protein-based therapies for chronic disease.
