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The tyrosine kinase receptor Axl induces efferocytosis, disrupts M1 responses, and promotes parasite infection and heart pathology in experimental Chagas disease.
The levels of catalytic subunit of the RNaseH2 enzyme, RNAseH2A, decrease during senescence promoting nucleotide accumulation and a senescence-associated secretory phenotype.
A field trial in Changsha, China, involving the release of a triple Wolbachia-infected strain of the mosquito, Aedes albopictus, demonstrates the feasibility of using an incompatible insect technique to suppress disease vector mosquito populations in urban subtropic environments.
Morphological and molecular phylogenetic analyses reveal six new species of mountain vole from China and climate drivers of mountain vole diversification.
A combination of experimental and literature analyses indicate that heat stress is a greater threat for coral calcification than ocean acidification, stressing the need for further investigation on key regulatory processes.
An integrated scRNA-seq and scATAC-seq analysis of retina from the goldfish, Carassius auratus, reveals global biases in expression patterns between the two (L and S) subgenomes that resulted from ancestral whole-genome duplication.
Regulatory T cells (Tregs) have similar immune profiles in tertiary lymphoid structures of lung cancer and non-TLS areas, with tumor-infiltrating Tregs found to inhibit the proliferation and cytokine secretion of CD4 + conventional T cells.
Nunavik Inuit gut microbiome retains a high intra-individual and lower inter-individual diversity, and is distinct from the gut microbiome of non-industrial and industrial populations
A study for human gut microbiota composition in 7 healthy Chinese adult subjects across several years provides a valuable perspective on the dynamics of microbiota composition over time.
An integrated genomic and transcriptomic analysis of progeny from reciprocal crosses between tetraploid and hexaploid wheat species reveals parental contributions to gene expression during various stages of seed development.
Direct modulation of the gut microbiota via rearing environments and fecal microbiota transplantation in a bleomycin-induced murine model suggests that a functional gut-lung axis modulates lung fibrosis.
A high-content screening assay based on a comprehensive set of cytological features, together with a robust statistical analysis workflow for profiling broad-based cellular phenotypic responses to small molecules or genetic perturbations.
Observational data and modeling are used to reveal the extent of direct and indirect effects of spiny water flea and zebra mussels on food-web processes that cancel shifts in water clarity.
CKRC3/TCU2 interacts with the NatB catalytic subunit to form a NatB complex, catalyzing the N-terminal acetylation of YUC proteins for their intracellular stability to maintain auxin homeostasis in plants.
A new species of Confuciusornis, a genus of basal birds from the Early Cretaceous, reveals that these early birds had stronger flight capability and more diverse flight modes than previously expected.
A synthetic method for the production of circularized DNA containing expression elements independent of plasmids is presented, taking linear double-stranded DNA fragments which are circularized and purified.