FOCUS
TGFβ SIGNALING
- Focus issue:
- January 2009 Volume 19, No 1
The collection of review and research articles in this web focus brings together our current understanding of TGFβ signaling. The accompanying special feature highlights the recent advances made in illustrating its molecular mechanisms, regulation and biological functions.
Articles
TGF-β-induced epithelial to mesenchymal transition FREE
Jian Xu, Samy Lamouille and Rik Derynck
Cell Research 19, 156–172 | doi:10.1038/cr.2009.5
Roles of TGFβ in metastasis FREE
David Padua and Joan Massagué
Cell Research 19, 89–102 | doi:10.1038/cr.2008.316
Signaling cross-talk between TGF-β/BMP and other pathways FREE
Xing Guo and Xiao-Fan Wang
Cell Research 19, 71–88 | doi:10.1038/cr.2008.302
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
Marko Pesu, Wendy T. Watford, Lai Wei, Lili Xu, Ivan Fuss, Warren Strober, John Andersson, Ethan M. Shevach, Martha Quezado, Nicolas Bouladoux, Anton Roebroek, Yasmine Belkaid, John Creemers and John J. O’Shea
Nature 455, 246–250 | doi:10.1038/nature06835
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
Morgan E. Carlson, Michael Hsu and Irina M. Conboy
Nature 454, 528–532 | doi:10.1038/nature07034
SMAD proteins control DROSHA-mediated microRNA maturation
Brandi N. Davis, Aaron C. Hilyard, Giorgio Lagna and Akiko Hata
Nature 454, 56–61 | doi:10.1038/nature07086
IL-21 and TGF-β are required for differentiation of human TH17 cells
Li Yang, David E. Anderson, Clare Baecher-Allan, William D. Hastings, Estelle Bettelli, Mohamed Oukka, Vijay K. Kuchroo and David A. Hafler
Nature 454, 350–352 | doi:10.1038/nature07021
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
Liang Zhou, Jared E. Lopes, Mark M. W. Chong, Ivaylo I. Ivanov, Roy Min, Gabriel D. Victora, Yuelei Shen, Jianguang Du, Yuri P. Rubtsov, Alexander Y. Rudensky, Steven F. Ziegler and Dan R. Littman
Nature 453, 236–240 | doi:10.1038/nature06878
The type I TGF-β receptor is covalently modified and regulated by sumoylation
Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst and Rik Derynck
Nature Cell Biology 10, 654–664 | doi:10.1038/ncb1728
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Nicolas Manel, Derya Unutmaz and Dan R Littman
Nature Immunology 9, 641–649 | doi:10.1038/ni.1610
A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
Yongzhong Liu, Pin Zhang, Jun Li, Ashok B Kulkarni, Sylvain Perruche and WanJun Chen
Nature Immunology 9, 632–640 | doi:10.1038/ni.1607
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