Senescence
Senescence and its potential contribution to cancer has often been overlooked, perhaps because it is easier to assess, both in vitro and in vivo, the net contribution of cell loss through death rather than permanent cell cycle arrest. However, many recent discoveries, aided in part by the availability of established markers of senescent cells in vivo, have rekindled interest in senescence as a tumour suppressive mechanism. This series of articles on senescence highlights the latest progress, and whether our increasing understanding of the mechanisms that trigger senescence might be useful for the development of innovative cancer therapies that enable patients to live long term with stable disease.
2010
January 2010 Vol 10 No 1
Senescence in tumours: evidence from mice and humans
Manuel Collado & Manuel Serrano
doi:10.1038/nrc2772
2009
February 2009 Vol 9 No 2
Senescence–messaging secretome: SMS–ing cellular stress
Thomas Kuilman and Daniel S. Peeper
doi:10.1038/nrc2560
2008
July 2008 Vol 8 No 7
Living on a break: cellular senescence as a DNA-damage response
Fabrizio d'Adda di Fagagna
doi:10.1038/nrc2440
June 2008 Vol 8 No 6
Telomere dysfunction and tumour suppression: the senescence connection
Yibin Deng, Suzanne Chan and Sandy Chang
doi:10.1038/nrc2393
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