Targeting the tumor microenvironment
- Submission status
- Closed
- Submission deadline
Many cancer treatments focus on aspects of the cancer cells themselves, including targeting genetic lesions or hyperactive signaling pathways within the tumor. However, tumor cells reside in a milieu of other cells, including cancer-associated fibroblasts, infiltrating immune cells, and blood vessels, which can promote cancer growth and act as a mechanism of treatment resistance. Other aspects of this environment, such as the extracellular matrix, can also act to promote tumor growth, resistance to treatment, and metastasis.
Additionally, the tumor itself can affect the environment to promote continued growth and metastasis, for instance, through lactate export. Therefore, targeting the tumor microenvironment may be particularly fruitful for reducing tumor growth and metastasis and blocking therapeutic resistance.
This Collection focuses on efforts to target all aspects of the tumor microenvironment, including drugs targeting infiltrating cell types, blocking interaction of tumor cells with the microenvironment, and mechanisms to block the pro-tumorigenic effect of cancer cells on their environment.
Editors
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Carrie House
San Diego State University, USA
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Sandeep Singh
National Institute of Biomedical Genomics, India
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Yoshikazu Yonemitsu
Kyushu University Graduate School of Pharmaceutical Sciences, Japan
Submitting a paper for consideration
To submit your manuscript for consideration at Scientific Reports as part of this Collection, please follow the steps detailed on this page. On the first page of our online submission system, under “I’m submitting:” select the option “any other article type”. Once logged in you can submit your manuscript to a Collection by selecting “Guest Edited Collection”, under the “Choose the appropriate manuscript type” message, and clicking “Continue”. Then when filling out the manuscript information, select the "Targeting the tumor microenvironment" Collection from the alphabetical list on the “Springer Nature Subject Category” tab. Authors should express their interest in the Collection in their cover letter.
Accepted papers are published on a rolling basis as soon as they are ready.
In addition to papers on Targeting the tumor microenvironment, Scientific Reports welcomes all original research in the field of Cell biology. To browse our latest articles in Cell biology click here.
