Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Icell Kealex Therapeutics is developing oncolytic vaccinia viruses armed with T-cell-engaging antibody fragments that boost the virus’s antitumor efficacy. The company is entering phase 1 trials for solid tumors with its lead product and is looking to partner with companies interested in clinical codevelopment of its wide-ranging therapeutic pipeline.
Oncolytic viruses developed to specifically destroy tumor cells are a potent form of immunotherapy, and consequently are finding their place in immunotherapy combination regimens. TILT Biotherapeutics’ oncolytic viruses enable solid tumor T cell therapy and checkpoint-inhibiting antibodies.
Temple Therapeutics BV’s first-in-class phase-3-ready drug candidate for postoperative fibrosis is ready for partnering for an untapped $5 billion market.
By improving single-cell analysis, Sphere Fluidics’ microfluidics technology is providing new options for antibody discovery and cell-line development.
Aposense is exploring an overlooked powerful electric field present at the depth of every biological membrane, in order to energize a pipeline of therapeutic opportunities.
Inhibition of host HO-1 reduces Mycobacterium tuberculosis (Mtb) growth in vivo and, more importantly, when used as an adjunct to conventional chemotherapy, results in a marked improvement in pulmonary bacterial control.
In vivo, administration of anti-CD300b antibodies protects animals from septic shock, due to a reduce level of pro-inflammatory cytokines but subsequent increase in the anti-inflammatory cytokine, IL-10.
Scientists at NIAID have developed nucleic acid-based vaccine candidates to prevent ZIKV infection in humans. The current lead candidate vaccine is a plasmid DNA vaccine demonstrated to accord protection in preclinical models and is undergoing clinical trial evaluation.Immunization with the nucleic acid ZIKV vaccine candidate results in production of noninfectious virus like particles (VLPs) made of ZIKV proteins.These ZIKV VLPs elicit an immune response which includes neutralizing antibodies to ZIKV.
The calcofluor derivatives disclosed in the patent application may be utilized as imaging agents specific for fungal infections and could potentially become a standard, non-invasive procedure in the work-up of immunocompromised patients with lung infections.
Available technology comprises live attenuated flavivirus vaccines, live attenuated multivalent flavivirus vaccines, and methods of preventing flavivirus infections as well as methods of making the vaccines.
Scientists at the National Institute of Allergy and Infectious Diseases (NIAID) have developed a novel bivalent vaccine candidate that may effectively prevent malaria and typhoid. This approach significantly enhances immune response to the Pfs25 Malaria transmission blocking antigen and produces a robust immune response against Salmonella typhi Vi polysaccharide (ViP).
Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa (“nanobodies”) with several advantages over conventional antibodies. The antibodies that were derived from llamas showed strong neutralizing activity against Norovirus in in vitro assays.