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Cardiac myosin inhibitors

Aficamten reduces cardiac contractility by modifying the actomyosin interaction

Nature Cardiovascular Research (2024)Cite this article

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Aficamten, a small-molecule myosin inhibitor, binds to the catalytic domain of cardiac myosin and reduces contraction by stabilizing the initial weak interaction between myosin and actin.

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Fig. 1: Aficamten modes of action.

References

  1. Lehman, S. J., Crocini, C. & Leinwand, L. A. Nat. Rev. Cardiol. 19, 353–363 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Maron, M. S. et al. N. Engl. J. Med. 390, 1849–1861 (2024).

    Article  CAS  PubMed  Google Scholar 

  3. Hartman, J. H. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00505-0 (2024).

    Article  Google Scholar 

  4. Scellini, B. et al. J. Gen. Physiol. 153, e202012789 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ma, W. et al. Circulation Res. 129, 617–630 (2021).

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, University of Washington City, Seattle, WA, USA

    Farid Moussavi-Harami

  2. Department of Laboratory Medicine and Pathology, University of Washington, City, Seattle, WA, USA

    Farid Moussavi-Harami & Michael Regnier

  3. Center for Translational Muscle Research, University of Washington, City, Seattle, WA, USA

    Farid Moussavi-Harami & Michael Regnier

  4. Center for Cardiovascular Biology, University of Washington City, Seattle, WA, USA

    Farid Moussavi-Harami & Michael Regnier

  5. Institute for Stem Cell and Regenerative Medicine, University of Washington City, Seattle, WA, USA

    Farid Moussavi-Harami & Michael Regnier

  6. Department of Bioengineering, University of Washington City, Seattle, WA, USA

    Michael Regnier

Authors
  1. Farid Moussavi-Harami
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  2. Michael Regnier
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Corresponding author

Correspondence to Michael Regnier.

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Competing interests

M.R. is a founder, board member and equity holder in StemCardia, Inc. and a scientific advisory board member and equity holder in Kineabio, Inc. F.M-H. declares no competing interests.

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Moussavi-Harami, F., Regnier, M. Aficamten reduces cardiac contractility by modifying the actomyosin interaction. Nat Cardiovasc Res (2024). https://doi.org/10.1038/s44161-024-00503-2

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