The mechanisms by which stroke and myocardial infarction trigger lymphocyte loss remain poorly defined. This study shows that the release of neutrophil extracellular traps (NETs) after stroke and myocardial infarction triggers B cell apoptosis and reduces the number of IgA-producing plasma cells. Therapeutic targeting of NETs is immunoprotective in mice and humans.
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References
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This is a summary of: Tuz, A. A. et al. Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00462-8 (2024).
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Neutrophil extracellular traps trigger IgA loss after stroke and myocardial infarction. Nat Cardiovasc Res (2024). https://doi.org/10.1038/s44161-024-00465-5
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DOI: https://doi.org/10.1038/s44161-024-00465-5
