The cellular microenvironment and interplay between cell types are essential for cardiac renewal. Combined single-cell and single-nucleus sequencing, spatial transcriptomics and loss-of-function experiments in constitutively YAP-expressing infarcted hearts reveal a cellular triad and complement signaling that evoke renewal of heart muscle.
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Riley, P.R. Cellular crosstalk to regenerate the injured heart. Nat Cardiovasc Res 3, 248–250 (2024). https://doi.org/10.1038/s44161-024-00426-y
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DOI: https://doi.org/10.1038/s44161-024-00426-y