Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Epicardium

Chasing youth on the outside: unique features of the human fetal epicardium

Nature Cardiovascular Research volume 1, pages 1130–1131 (2022)Cite this article

Subjects

The epicardium has an active role in the formation of fetal and neonatal mammalian hearts, which retain the ability to regenerate. A single-cell comparison of human fetal and adult epicardial cells defines the transcriptomic programs that are specific to the fetal epicardium that could be harnessed to repair the injured adult heart.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Activity of the human epicardium.

References

  1. Garbern, J. C. & Lee, R. T. Dev. Cell 57, 424–439 (2022).

    Article  CAS  Google Scholar 

  2. Wang, J., Cao, J., Dickson, A. L. & Poss, K. D. Nature 522, 226–230 (2015).

    Article  CAS  Google Scholar 

  3. Smits, A. M., Dronkers, E. & Goumans, M. J. Pharmacol. Res. 127, 129–140 (2017).

    Article  Google Scholar 

  4. Duan, J. et al. EMBO J. 31, 429–442 (2011).

    Article  Google Scholar 

  5. Smart, N. et al. Nature 474, 640–644 (2011).

    Article  CAS  Google Scholar 

  6. Streef, T. J. & Smits, A. M. Front. Cardiovasc. Med. 8, 1–16 (2021).

    Article  Google Scholar 

  7. Knight-Schrijver, V. R. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00183-w (2022).

    Article  Google Scholar 

  8. Redpath, A. N. & Smart, N. Stem Cells Transl. Med. 10, 511–521 (2021).

    Article  Google Scholar 

  9. Moerkamp, A. T. et al. Stem Cell Res. Ther. 7, 1–12 (2016).

    Article  Google Scholar 

  10. Zhou, B. et al. J. Clin. Invest. 121, 1894–1904 (2011).

    Article  CAS  Google Scholar 

  11. Nakamura, K. et al. J. Biol. Chem. 291, 2566–2575 (2016).

    Article  CAS  Google Scholar 

  12. Blankesteijn, W. M. Mol. Pharmacol. 97, 90–101 (2020).

    Article  CAS  Google Scholar 

  13. Winter, E. M. et al. Circulation 116, 917–927 (2007).

    Article  CAS  Google Scholar 

  14. Smart, N. et al. Nature 474, 640–644 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands

    Anke M. Smits & Marie Jose Goumans

Authors
  1. Anke M. Smits
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie Jose Goumans
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Anke M. Smits or Marie Jose Goumans.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Smits, A.M., Goumans, M.J. Chasing youth on the outside: unique features of the human fetal epicardium. Nat Cardiovasc Res 1, 1130–1131 (2022). https://doi.org/10.1038/s44161-022-00191-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-022-00191-w

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing