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Aortic-intima-resident macrophages are guardians of arterial health

Nature Cardiovascular Research volume 1, pages 4–5 (2022)Cite this article

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Aortic-intima-resident macrophages (MACAIRs) share the vessel luminal lining with endothelial cells in areas of turbulent flow and protrude into the arterial blood stream to clean the inner arterial surface via phagocytosis, shield nearby endothelial cells from activation by thrombin and prevent microthrombus formation.

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Fig. 1: MacAIRs are neighbors of endothelial cells.

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Authors and Affiliations

  1. Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Fadi E. Pulous & Matthias Nahrendorf

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  1. Fadi E. Pulous
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  2. Matthias Nahrendorf
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Correspondence to Matthias Nahrendorf.

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Competing interests

M.N. has received funds or material research support from Alnylam, Biotronik, CSL Behring, GlycoMimetics, GSK, Medtronic, Novartis and Pfizer, as well as consulting fees from Biogen, Gimv, IFM Therapeutics, Molecular Imaging, Sigilon and Verseau Therapeutics. F.E.P. declares no competing interests.

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Pulous, F.E., Nahrendorf, M. Aortic-intima-resident macrophages are guardians of arterial health. Nat Cardiovasc Res 1, 4–5 (2022). https://doi.org/10.1038/s44161-021-00008-2

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