Late-stage tritiation with high selectivity, isotopic purity and functional-group tolerance is important for the radiolabelling of drug candidates or bioactive compounds. Now, a broadly applicable protocol using aryl thianthrenium salts allows for tritiation of complex molecules by hydrogenolysis via an intermediate cationic palladium complex.
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Sarbajna, A., Gessner, V.H. Tritiation gets selective. Nat Synth 1, 16–17 (2022). https://doi.org/10.1038/s44160-021-00009-w
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DOI: https://doi.org/10.1038/s44160-021-00009-w