We present a method to alleviate re-identification risks behind sharing haplotype reference panels for imputation. In an anonymized reference panel, one might try to infer the genomes’ phenotypes to re-identify their owner. Our method protects against such attack by shuffling the reference panels genomes while maintaining imputation accuracy.
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References
Das, S., Abecasis, G. R. & Browning, B. L. Genotype imputation from large reference panels. Annu. Rev. Genomics Hum. Genet. 31, 73–96 (2018). A review article that presents an overview of genotype imputation and that describes imputation techniques relying on large reference panels.
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This is a summary of: Cavinato, T. et al. A resampling-based approach to share reference panels. Nat. Comput. Sci. https://doi.org/10.1038/s43588-024-00630-7 (2024).
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Shuffling haplotypes to share reference panels for imputation. Nat Comput Sci 4, 320–321 (2024). https://doi.org/10.1038/s43588-024-00640-5
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DOI: https://doi.org/10.1038/s43588-024-00640-5
