An image-inspired deep-learning model is developed to generate realistic de novo protein structures and scaffolds around functional sites, which helps the search for new structures and functions in protein engineering.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jumper, J. et al. Nature 596, 583–589 (2021).
Dauparas, J. et al. Science 378, 49–56 (2022).
Lee, J. S., Kim, J. & Kim, P. M. Nat. Comput. Sci. https://doi.org/10.1038/s43588-023-00440-3 (2023).
Ho, J., Jain, A. & Abbeel, P. Adv. Neural Inf. Process. Syst. 33, 6840–6851 (2020).
Song, Y. & Ermon, S. Adv. Neural Inf. Process. Syst. 32, 11918–11930 (2019).
Ramesh, A., Dhariwal, P., Nichol, A., Chu, C. & Chen, M. Preprint at https://arxiv.org/abs/2204.06125 (2022).
Anand, N. & Achim, T. Preprint at https://arxiv.org/abs/2205.15019 (2022).
Trippe, B. L. et al. Preprint https://arxiv.org/abs/2206.04119 (2022).
Wu, K. E. et al. Preprint at https://arxiv.org/abs/2209.15611 (2022).
Lin, Y. & AlQuraishi, M. Preprint https://arxiv.org/abs/2301.12485 (2023).
Leman, J. K. et al. Nat. Methods 17, 665–680 (2020).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Amini, A.P., Yang, K.K. From noise to protein with image models. Nat Comput Sci 3, 366–367 (2023). https://doi.org/10.1038/s43588-023-00454-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43588-023-00454-x
