Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Epigenetic clocks

Epigenetic clock work ticks forward

Nature Aging volume 4, pages 170–172 (2024)Cite this article

Subjects

Ying et al. integrate Mendelian randomization into epigenetic clock making and pioneer a strategy to develop aging biomarkers with stronger causal ties to healthspan. They distinguish signs of aging-related molecular damage from responses to it that might signal resilience.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Typology of age-associated CpG sites revealed by Mendelian randomization analysis of healthspan and longevity.

References

  1. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 186, 243–278 (2023).

    Article  PubMed  Google Scholar 

  2. Horvath, S. Genome Biol. 14, R115 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hannum, G. et al. Mol. Cell 49, 359–367 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Ying, K. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00557-0 (2024).

    Article  PubMed  Google Scholar 

  5. Imbens, G. W. & Angrist, J. D. Econometrica 62, 467–475 (1994).

    Article  Google Scholar 

  6. Davey Smith, G. & Hemani, G. Hum. Mol. Genet. 23 R1, R89–R98 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Min, J. L. et al. Nat. Genet. 53, 1311–1321 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Gladyshev, V. N. et al. Nat. Aging 1, 1096–1106 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Levine, M. E. et al. Aging 10, 573–591 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Lu, A. T. et al. Aging 11, 303–327 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Belsky, D. W. et al. eLife 11, e73420 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Puri, D. & Wagner, W. Mol. Cell. Dev. Biol. 45, e2200208 (2023).

    Google Scholar 

  13. Ying, K. et al. Preprint at bioRxiv, https://doi.org/10.1101/2023.12.02.569722 (2023).

  14. Oh, H. S.-H. et al. Nature 624, 164–172 (2023).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

D.W.B. is a fellow of the CIFAR CBD Network.

Author information

Authors and Affiliations

  1. Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA

    C. P. Ryan & D. W. Belsky

  2. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA

    D. W. Belsky

Authors
  1. C. P. Ryan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. W. Belsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. W. Belsky.

Ethics declarations

Competing interests

D.W.B. is listed as an inventor of the Duke University and University of Otago invention DunedinPACE, which is licensed to TruDiagnostic. C.P.R. declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ryan, C.P., Belsky, D.W. Epigenetic clock work ticks forward. Nat Aging 4, 170–172 (2024). https://doi.org/10.1038/s43587-024-00570-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-024-00570-x

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing