Aging is a major risk factor for vascular disease. Increased levels of milk fat globule-EGF factor 8 (MFG-E8) are associated with many age-related arterial changes, but the mechanisms remain unclear. We propose that these detrimental effects may result from medin, a fragment of MFG-E8 that forms a highly common vascular amyloid.
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Acknowledgements
This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) to J.J.N. (NE 1951/2-1 and -2), and VA Merit BX003767 and NIH R21AG075543 grants to J.M. and R.Q.M.
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A patent application for anti-medin immunotherapy has been submitted by the US Department of Veterans Affairs (inventors: J.M., R.Q.M.). The other authors declare no competing interests.
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Madine, J., Davies, H.A., Migrino, R.Q. et al. Medin amyloid may drive arterial aging and disease in the periphery and brain. Nat Aging 3, 1039–1041 (2023). https://doi.org/10.1038/s43587-023-00481-3
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DOI: https://doi.org/10.1038/s43587-023-00481-3