Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Intestinal aging

Deteriorating maintenance of the intestinal wall

Nature Aging volume 3, pages 1046–1047 (2023)Cite this article

Subjects

Intestinal barrier dysfunction is a hallmark of aging. Zhang and colleagues examine the replenishment of adherens junctions in the intestine of aged Caenorhabditis elegans and discover the role of the SDPN-1–RAB-10 axis in the dysregulated endocytic recycling, offering new insights into the age-dependent impairment of the intestinal barrier.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Deteriorating maintenance of the intestinal barrier during aging.

References

  1. Salazar, A. M., Aparicio, R., Clark, R. I., Rera, M. & Walker, D. W. Dis. Model. Mech. 16, dmm049969 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Brüser, L. & Bogdan, S. Cold Spring Harb. Perspect. Biol. 9, a029140 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Odenwald, M. A. & Turner, J. R. Nat. Rev. Gastroenterol. Hepatol. 14, 9–21 (2017).

    Article  CAS  PubMed  Google Scholar 

  4. Zhang, J. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00475-1 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Mack, H. I. D., Heimbucher, T. & Murphy, C. T. Drug Discov. Today Dis. Models 27, 3–13 (2018).

    Article  Google Scholar 

  6. Chen, C. C. et al. Mol. Biol. Cell 17, 1286–1297 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Grant, B. D. & Donaldson, J. G. Nat. Rev. Mol. Cell Biol. 10, 597–608 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Liu, H. et al. J. Cell Biol. 217, 299–314 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Egge, N. et al. Dev. Cell 51, 587–601.e7 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Capitani, N. & Baldari, C. T. Front. Cell Dev. Biol. 9, 670882 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Akerfelt, M., Morimoto, R. I. & Sistonen, L. Nat. Rev. Mol. Cell Biol. 11, 545–555 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Parrish, A. R. Tissue Barriers 5, e1343172 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China

    Yifan Chen & Yidong Shen

  2. University of Chinese Academy of Sciences, Beijing, China

    Yifan Chen & Yidong Shen

Authors
  1. Yifan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yidong Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yidong Shen.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, Y., Shen, Y. Deteriorating maintenance of the intestinal wall. Nat Aging 3, 1046–1047 (2023). https://doi.org/10.1038/s43587-023-00477-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-023-00477-z

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing