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Longevity

Deadly males accelerate aging with piRNAs

Nature Aging volume 3, pages 7–8 (2023)Cite this article

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Mating is known to accelerate the aging of the opposite sex in a variety of species. A transcriptomic analysis of extracted germlines from mated and unmated Caenorhabditis elegans by Shi and Murphy now identifies a Piwi-interacting RNA-to-Hedgehog signaling pathway that regulates the accelerated aging of hermaphrodites.

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Fig. 1: Males accelerate aging in hermaphrodite C. elegans through several signaling pathways.

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Acknowledgements

The author thanks E. Pollina for critically reading the manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA

    Eric Lieberman Greer

  2. Division of Newborn Medicine, Boston Children’s Hospital, Boston, MA, USA

    Eric Lieberman Greer

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  1. Eric Lieberman Greer
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Correspondence to Eric Lieberman Greer.

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The author declares no competing interests.

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Greer, E.L. Deadly males accelerate aging with piRNAs. Nat Aging 3, 7–8 (2023). https://doi.org/10.1038/s43587-022-00347-0

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