There are no current standard-of-care treatments for sarcopenia, an age-associated decline in muscle mass and strength. A new study shows that genetically or pharmacologically countering the age-associated accumulation of sphingolipids in skeletal muscle can ameliorate sarcopenia in mice. The authors also identify genetic variants linked to sphingolipid biosynthesis that associate with muscle function in aged humans.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Melton, L. J. III et al. J. Am. Geriatr. Soc. 48, 625–630 (2000).
Laurila, P.-P. et al. Nat. Aging https://doi.org/10.1038/s435870-022-00309-6(2022).
Summers, S. A., Chaurasia, B. & Holland, W. L. Nat. Metab. 1, 1051–1058 (2019).
Nicholson, R. J., Norris, M. K., Poss, A. M., Holland, W. L. & Summers, S. A. Annu. Rev. Nutr. 42, 115–144 (2022).
Deschenes, M. R. Sports Med. 34, 809–824 (2004).
Summers, S. A., Garza, L. A., Zhou, H. & Birnbaum, M. J. Mol. Cell. Biol. 18, 5457–5464 (1998).
Brockman, H. L. et al. Biophys. J. 87, 1722–1731 (2004).
Park, M. et al. J. Biol. Chem. 291, 23978–23988 (2016).
Chaurasia, B. & Summers, S. A. Annu. Rev. Physiol. 83, 303–330 (2021).
Barbarroja, N. et al. Diabetes 64, 1180–1192 (2015).
Patrizio, E., Calvani, R., Marzetti, E. & Cesari, M. J. Frailty Aging 10, 141–149 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Miranda, E.R., Funai, K. Suppression of de novo sphingolipid biosynthesis mitigates sarcopenia. Nat Aging 2, 1088–1089 (2022). https://doi.org/10.1038/s43587-022-00307-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43587-022-00307-8