Our longitudinal study comparing the skin, gut and oral microbiomes of community-dwelling older adults and nursing home residents showed striking changes known to be linked to antibiotic resistance and disease risk. Such shifts were associated with frailty, not chronological age, and were most pronounced in the skin, the primary reservoir for infection risk.
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References
Franceschi, C. et al. The continuum of aging and age-related diseases: common mechanisms but different rates. Front. Med. (Lausanne) 5, 61 (2018). A Review article that discusses heterogeneity in aging phenotypes.
Kim, I. & Benayoun, B. A. The microbiome: an emerging key player in aging and longevity. Transl. Med. Aging 4, 103–116 (2020). This Review discusses the gut microbiome as an emerging player in aging.
Claesson, M. J. et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 488, 178–184 (2012). This paper reports differences in the gut microbiota of residents of nursing facilities.
Haran, J. P. The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location. J. Med. Microbiol. 67, 40–51 (2018). A paper that associates the nursing home environment with the microbiome and aging phenotypes.
Oh, J. Shifts in human skin and nares microbiota of healthy children and adults. Genome Med. 4, 77 (2012). This paper shows that the skin microbiota is remodeled during puberty.
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This is a summary of: Larson, P. J. et al. Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults. Nat. Aging https://doi.org/10.1038/s43587-022-00287-9 (2022).
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Frailty-associated dysbiosis of human microbiotas in older adults in nursing homes. Nat Aging 2, 876–877 (2022). https://doi.org/10.1038/s43587-022-00289-7
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DOI: https://doi.org/10.1038/s43587-022-00289-7
