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ALZHEIMER’S DISEASE

Reducing decoys focuses fighting microglia

Nature Aging volume 2, pages 573–575 (2022)Cite this article

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Genetic variation linked to lower levels of soluble ST2, a decoy cytokine receptor for IL-33, may protect against Alzheimer’s disease in women carrying the APOEε4 allele by increasing microglial plaque removal. This discovery advances our understanding of the immune system’s role in Alzheimer’s disease and underscores the importance of sex-specific disease processes.

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Fig. 1: sST2 increases Alzheimer’s disease risk by limiting microglial clearance of Aβ plaques.

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Acknowledgements

The authors are supported by the Intramural Research Program of the NIH, National Institute on Aging.

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  1. Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA

    Michael R. Duggan & Keenan A. Walker

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  1. Michael R. Duggan
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  2. Keenan A. Walker
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Correspondence to Keenan A. Walker.

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The authors declare no competing interests.

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Duggan, M.R., Walker, K.A. Reducing decoys focuses fighting microglia. Nat Aging 2, 573–575 (2022). https://doi.org/10.1038/s43587-022-00251-7

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