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CELL BIOLOGY

Mitochondrial carriers set the epigenetic age

Nature Aging volume 1, pages 755–756 (2021)Cite this article

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New research reveals that the mitochondrial citrate carrier is crucial for the accumulation of acetyl-CoA in the cytosol and nucleus, and efficient histone acetylation. Lysosomal degradation of this carrier drives mesenchymal stem cell aging in a process characterized by tightly packed chromatin and reduced expression of osteogenic genes.

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Fig. 1: The levels of the mitochondrial citrate carrier determine nuclear gene expression patterns.

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Authors and Affiliations

  1. Cell Biology, University of Kaiserslautern, Kaiserslautern, Germany

    Carina Groh & Johannes M. Herrmann

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  1. Carina Groh
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  2. Johannes M. Herrmann
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Correspondence to Johannes M. Herrmann.

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The authors declare no competing interests.

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Groh, C., Herrmann, J.M. Mitochondrial carriers set the epigenetic age. Nat Aging 1, 755–756 (2021). https://doi.org/10.1038/s43587-021-00111-w

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