Antigen presentation is fundamental to anti-tumor immunity, but our understanding of the physiological and molecular inputs to the process in different contexts remains limited. Two new studies explore the contribution of cell-intrinsic proteolytic mechanisms and cell-extrinsic hot and cold tumor microenvironments in shaping the antigenic landscape in lung cancer.
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Stewart, P.A., Jaeger, A.M. Taking the temperature of lung cancer antigens. Nat Cancer 4, 586–587 (2023). https://doi.org/10.1038/s43018-023-00552-9
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DOI: https://doi.org/10.1038/s43018-023-00552-9