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Cancer immunotherapy

LINKing signaling domains to enhance CAR T cells

Nature Cancer volume 4, pages 447–449 (2023)Cite this article

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The lack of tumor-specific surface antigens has limited the application of CAR T cells in solid tumors. A new AND-gated CAR T cell system repurposes proximal T cell signaling proteins to restrict activation to dual antigen encounter, mitigating on-target, off-tumor toxicity while preserving antitumor efficacy in preclinical models.

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Fig. 1: Leveraging the cooperative role of LAT and SLP-76 in LINK CARs to prevent on-target, off-tumor toxicity.

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Authors and Affiliations

  1. Cluster of Excellence iFIT (EXC2180) “Image-guided and Functionally Instructed Tumor Therapies,” University of Tübingen, Tübingen, Germany

    Philip Bucher & Judith Feucht

  2. Department of Pediatric Hematology and Oncology, University Children’s Hospital, University of Tübingen, Tübingen, Germany

    Philip Bucher & Judith Feucht

Authors
  1. Philip Bucher
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  2. Judith Feucht
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Correspondence to Judith Feucht.

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Competing interests

P.B. declares no financial interests. J.F. is listed as co-inventor of several patents on CAR technologies unrelated to the subject matter of this study.

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Bucher, P., Feucht, J. LINKing signaling domains to enhance CAR T cells. Nat Cancer 4, 447–449 (2023). https://doi.org/10.1038/s43018-023-00538-7

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