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Metastasis

The aging lung reawakens dormant tumor cells

Nature Cancer volume 4, pages 442–443 (2023)Cite this article

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As we age, organs undergo architectural and functional changes that deeply affect the fate of disseminated tumor cells (DTCs). A study now adds further complexity to this picture by revealing a role for the age-induced, fibrosis-associated factor PDGF-C in enabling ER+ DTCs to reawaken in aging lungs and thrive as overt metastasis.

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Fig. 1: A role of age-induced PDGF-C in ER+ DTC reawakening and metastasis formation.

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Authors and Affiliations

  1. Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA

    Stanislav Drapela & Ana P. Gomes

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  1. Stanislav Drapela
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  2. Ana P. Gomes
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Correspondence to Ana P. Gomes.

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The authors declare no competing interests.

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Drapela, S., Gomes, A.P. The aging lung reawakens dormant tumor cells. Nat Cancer 4, 442–443 (2023). https://doi.org/10.1038/s43018-023-00537-8

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