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Cardiac metabolism

Bile acids for diabetic cardiomyopathy

Nature Metabolism (2024)Cite this article

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Diabetes can cause heart failure by a toxic accumulation of lipids in cardiac myocytes, which impairs their function. This work shows that stimulation of the bile acid receptor TGR5 limits fatty acid uptake into cardiac myocytes and prevents the development of diabetic cardiomyopathy.

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Fig. 1: Impact of TGR5 activation and deletion on cardiac fatty acid metabolism in diabetic cardiomyopathy (DbCM).

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Acknowledgements

Christoph Maack is funded by the Deutsche Forschungsgemeinschaft (DFG; Ma 2528/8–1, SFB 1525 — project no. 453989101), the German Center for Cardiovascular Research (DZHK) (EX-22) and the COST Action CA22169 (EU-METAHEART).

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Authors and Affiliations

  1. Department of Translational Research, Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany

    David Weissman & Christoph Maack

  2. Medical Clinic I, University Hospital Würzburg, Würzburg, Germany

    Christoph Maack

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  1. David Weissman
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  2. Christoph Maack
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Correspondence to Christoph Maack.

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Competing interests

C.M. is an advisor to Amgen, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Novo Nordisk and Servier, and received speaker honoraria from AstraZeneca, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Berlin Chemie, Edwards, Novartis, Novo Nordisk and Servier. D.W. declares no competing interests.

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Weissman, D., Maack, C. Bile acids for diabetic cardiomyopathy. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01032-9

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