Stress is an important risk factor for neuropsychiatric disorders such as major depression, but the underlying biological mechanisms remain largely unclear. A recent study has revealed a mechanism that regulates neuronal metabolism and mitochondrial function, and thereby drives stress susceptibility and disease outcomes.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
GBD 2019 Mental Disorders Collaborators. Lancet Psychiatry 9, 137–150 (2022).
Dong, W.-T. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00924-6 (2023).
Picard, M., McEwen, B. S., Epel, E. S. & Sandi, C. Front. Neuroendocrinol. 49, 72–85 (2018).
Ghosal, S. et al. Cell Rep 42, 112776 (2023).
Hollis, F., Pope, B. S., Gorman-Sandler, E. & Wood, S. K. in Neuroscience of Social Stress (eds Miczek, K. A. & Sinha, R.) 59–93 (Springer International, 2022).
Howard, D. M. et al. Nat. Neurosci. 22, 343–352 (2019).
von Mücke-Heim, I.-A. et al. Mol. Psychiatry 28, 329–340 (2023).
Ayash, S. et al. Proc. Natl Acad. Sci. USA 120, e2205576120 (2023).
Bordes, J. et al. Nat. Commun. 14, 4319 (2023).
Kaluve, A. M., Le, J. T. & Graham, B. M. Neurosci. Biobehav. Rev. 143, 104962 (2022).
van Doeselaar, L. et al. Stress 24, 168–180 (2021).
Kuehner, C. Lancet Psychiatry 4, 146–158 (2017).
Bangasser, D. A. & Cuarenta, A. Nat. Rev. Neurosci. 22, 674–684 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Schmidt, M.V. Linking neuropsychiatric disease to neuronal metabolism. Nat Metab 5, 2041–2042 (2023). https://doi.org/10.1038/s42255-023-00929-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-023-00929-1