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Cellular metabolism

Cholesterol drives inflammatory senescence

Both cell cycle arrest and secretions of senescent cells are subject to metabolic control. In this issue of Nature Metabolism, Roh et al. show that lysosomal partitioning of cholesterol potentiates inflammatory secretion during senescence.

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Fig. 1: Cholesterol partitioning controls senescence phenotypes.

References

  1. Childs, B. G. et al. Nat. Rev. Drug Discov. 16, 718–735 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. He, S. & Sharpless, N. E. Cell 169, 1000–1011 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J. & Kirkland, J. L. J. Clin. Invest. 123, 966–972 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Coppé, J. P. et al. PLoS Biol. 6, 2853–2868 (2008).

    Article  PubMed  Google Scholar 

  5. Basisty, N. et al. PLoS Biol. 18, e3000599 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Takasugi, M. Aging Cell 17, e12734 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Wiley, C. D. et al. Cell Metab. 33, 1124–1136.e5 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wiley, C. D. & Campisi, J. Nat. Metab. 3, 1290–1301 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Roh, K. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00747-5 (2023).

    Article  PubMed  Google Scholar 

  10. Jeon, O. H. et al. Nat. Med. 23, 775–781 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Moon, S. H. et al. Cell 176, 564–580.e19 (2019).

    Article  CAS  PubMed  Google Scholar 

  12. Liu, S. et al. Sci. Rep. 5, 17895 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Tabas, I. J. Clin. Invest. 110, 905–911 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Chang, J. et al. Nat. Med. 22, 78–83 (2016).

    Article  CAS  PubMed  Google Scholar 

  15. Zhu, Y. et al. Aging (Albany NY) 9, 955–963 (2017).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Christopher D. Wiley.

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Competing interests

C.W. is an inventor on a patent application by Tufts University involving lipid and sterol metabolism as a mechanism for senescent cell elimination (US Application 63/264,510 T002531 US.PRO). C.K. declares no competing interests.

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Kuehnemann, C., Wiley, C.D. Cholesterol drives inflammatory senescence. Nat Metab 5, 355–356 (2023). https://doi.org/10.1038/s42255-023-00758-2

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