Hepatocellular carcinoma (HCC) is the 4th leading cause of cancer mortality. Modulation of tumour metabolism may represent a novel therapeutic strategy. Hexokinase 1, secreted into extracellular vesicles by activated hepatic stellate cells, is shown to be taken up by tumour cells, where it accelerates glycolysis and HCC growth.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Llovet, J. M. et al. Nat. Rev. Dis. Primers 7, 6 (2021).
Younossi, Z. M. & Henry, L. JHEP Rep 3, 100305 (2021).
Llovet, J. M. et al. Nat. Rev. Clin. Oncol. 19, 151–172 (2022).
Satriano, L., Lewinska, M., Rodrigues, P. M., Banales, J. M. & Andersen, J. B. Nat. Rev. Gastroenterol. Hepatol. 16, 748–766 (2019).
Wilson, J. E. J. Exp. Biol. 206, 2049–2057 (2003).
Ciscato, F., Ferrone, L., Masgras, I., Laquatra, C. & Rasola, A. Int. J. Mol. Sci. 22, 4716 (2021).
DeWaal, D. et al. Nat. Commun. 9, 446 (2018).
Xu, S. et al. Cancer Metab. 6, 7 (2018).
Chen, Q. T. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00642-5 (2022).
Mederacke, I. et al. Nat. Commun. 4, 2823 (2013).
Bian, X. L. et al. Nat. Commun. 8, 14420 (2017).
Lujambio, A. et al. Cell 153, 449–460 (2013).
Duran, A. et al. Cancer Cell 30, 595–609 (2016).
Perrin-Cocon, L. et al. Commun. Biol. 4, 217 (2021).
Lawitz, E. J. et al. Hepatology 75, 912–923 (2022).
Acknowledgements
RFS is supported by NIH grants 5R01CA262424-02 and 1R01CA262424-01.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Filliol, A., Schwabe, R.F. Liver cancer metabolism: a hexokinase from the stars. Nat Metab 4, 1225–1226 (2022). https://doi.org/10.1038/s42255-022-00659-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-022-00659-w