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Co-receptor regulation of insulin signaling

Nature Metabolism volume 4, pages 1093–1094 (2022)Cite this article

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Decreased insulin action and insulin receptor signalling contribute to the pathology of diabetes. Liu et al. uncover a role for the Ephrin type-B receptor 4 in insulin receptor degradation regulating liver and systemic insulin sensitivity.

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Fig. 1: An expanding family of co-receptor mediated endocytosis, degradation and recycling of the activated insulin–INSR complex.

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Authors and Affiliations

  1. Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Munich, Germany

    Prisca Chapouton & Heiko Lickert

  2. German Center for Diabetes Research (DZD), Munich, Germany

    Prisca Chapouton & Heiko Lickert

  3. School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

    Heiko Lickert

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  1. Prisca Chapouton
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  2. Heiko Lickert
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Correspondence to Heiko Lickert.

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The authors declare no competing interests.

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Chapouton, P., Lickert, H. Co-receptor regulation of insulin signaling. Nat Metab 4, 1093–1094 (2022). https://doi.org/10.1038/s42255-022-00641-6

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