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MITOCHONDRIA

Mitochondrial H+ permeability through the ADP/ATP carrier

Mitochondrial H+ leak, which is responsible for basal respiration, appears to be a transport process mediated by the ADP/ATP carrier and regulated by fatty acids and adenine nucleotides.

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Fig. 1: Mechanism of H+ transport by the adenine nucleotide carrier and uncoupling protein 1.

References

  1. Bertholet, A. M. et al. Nature https://doi.org/10.1038/s41586-019-1400-3 (2019).

    Article  CAS  Google Scholar 

  2. Aquila, H., Link, T. A. & Klingenberg, M. EMBO J. 4, 2369–2376 (1985).

    Article  CAS  Google Scholar 

  3. Fedorenko, A., Lishko, P. V. & Kirichok, Y. Cell 151, 400–413 (2012).

    Article  CAS  Google Scholar 

  4. Palmieri, F. & Monné, M. Biochim. Biophys. Acta 1863, 2362–2378 (2016).

    Article  CAS  Google Scholar 

  5. Rafael, J. & Heldt, H. W. FEBS Lett. 63, 304–308 (1976).

    Article  CAS  Google Scholar 

  6. Nicholls, D. G. Eur. J. Biochem. 62, 223–228 (1976).

    Article  CAS  Google Scholar 

  7. Klingenberg, M. & Rottenberg, H. Eur. J. Biochem. 73, 125–130 (1977).

    Article  CAS  Google Scholar 

  8. Watt, I. N., Montgomery, M. G., Runswick, M. J., Leslie, A. G. & Walker, J. E. Proc. Natl Acad. Sci. USA 107, 16823–16827 (2010).

    Article  CAS  Google Scholar 

  9. Wojtczak, L. & Zaluska, H. Biochem. Biophys. Res. Commun. 28, 76–81 (1967).

    Article  CAS  Google Scholar 

  10. Andreyev, A. Y. et al. FEBS Lett. 226, 265–269 (1988).

    Article  Google Scholar 

  11. Lin, C. S. & Klingenberg, M. Biochemistry 21, 2950–2956 (1982).

    Article  CAS  Google Scholar 

  12. Bouillaud, F., Alves-Guerra, M. C. & Ricquier, D. Biochim. Biophys. Acta 1863, 2443–2456 (2016).

    Article  CAS  Google Scholar 

  13. Penzo, D., Tagliapietra, C., Colonna, R., Petronilli, V. & Bernardi, P. Biochim. Biophys. Acta 1555, 160–165 (2002).

    Article  CAS  Google Scholar 

  14. Brustovetsky, N., Tropschug, M., Heimpel, S., Heidkämper, D. & Klingenberg, M. Biochemistry 41, 11804–11811 (2002).

    Article  CAS  Google Scholar 

  15. Skulachev, V. P. Q. Rev. Biophys. 29, 169–202 (1996).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Paolo Bernardi.

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Bernardi, P. Mitochondrial H+ permeability through the ADP/ATP carrier. Nat Metab 1, 752–753 (2019). https://doi.org/10.1038/s42255-019-0079-y

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