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Organic chemistry

A radical strategy towards ortho-amination reactions

Nature Catalysis volume 7, pages 611–612 (2024)Cite this article

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A combination of an iron(ii)-catalyst and a hydroxylammonium salt enables the direct and selective conversion of an inert aromatic C–H bond to a valuable, unprotected amine functionality. This approach solves a long standing challenge in modern synthesis.

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Fig. 1: Catalytic ortho-amination of arenes.

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Authors and Affiliations

  1. Institute of Organic Chemistry, RWTH Aachen University, Aachen, Germany

    Quoc Hoang Pham & Rene M. Koenigs

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  1. Quoc Hoang Pham
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  2. Rene M. Koenigs
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Correspondence to Rene M. Koenigs.

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The authors declare no competing interests.

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Pham, Q.H., Koenigs, R.M. A radical strategy towards ortho-amination reactions. Nat Catal 7, 611–612 (2024). https://doi.org/10.1038/s41929-024-01178-5

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