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Asymmetric catalysis

Stereoselective alkyl–alkyl cross-coupling

Nature Catalysis volume 5, pages 1079–1080 (2022)Cite this article

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An Author Correction to this article was published on 11 January 2023

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Controlling the stereochemical outcomes of chemical reactions is essential in modern chemical synthesis and manufacturing. Now, a nickel-catalysed, stereoselective hydrometalation and enantioconvergent alkyl–alkyl coupling of alkenyl boronic esters and α-bromo carbonyl derivatives has been achieved to provide single stereoisomers.

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Fig. 1: Nickel-catalysed enantioconvergent cross-coupling reactions.

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  1. Department of Chemistry, The University of Warwick, Coventry, UK

    Mark D. Greenhalgh

  2. EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh, UK

    Stephen P. Thomas

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  1. Mark D. Greenhalgh
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  2. Stephen P. Thomas
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Correspondence to Mark D. Greenhalgh or Stephen P. Thomas.

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Greenhalgh, M.D., Thomas, S.P. Stereoselective alkyl–alkyl cross-coupling. Nat Catal 5, 1079–1080 (2022). https://doi.org/10.1038/s41929-022-00897-x

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