A crucial malonic acid moiety in the antibiotic malonomycin has been shown to be installed by a bacterial vitamin K-dependent (VKD) carboxylase orthologue.
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Cryle, M.J. Pathway to malonic acid-containing metabolites. Nat Catal 1, 907–908 (2018). https://doi.org/10.1038/s41929-018-0191-5
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DOI: https://doi.org/10.1038/s41929-018-0191-5