Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NATURAL PRODUCT BIOSYNTHESIS

Pathway to malonic acid-containing metabolites

A crucial malonic acid moiety in the antibiotic malonomycin has been shown to be installed by a bacterial vitamin K-dependent (VKD) carboxylase orthologue.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Overview of malonomycin biosynthesis.

References

  1. Newman, D. J. & Cragg, G. M. J. Nat. Prod. 79, 629–661 (2016).

    Article  CAS  PubMed  Google Scholar 

  2. Dodge, G. J., Maloney, F. P. & Smith, J. L. Nat. Prod. Rep. 35, 1082–1096 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Izoré, T. & Cryle, M. J. Nat. Prod. Rep. https://doi.org/10.1039/C8NP00038G (2018).

    Article  PubMed  Google Scholar 

  4. Law, B. J. C. et al. Nat. Catal. https://doi.org/10.1038/s41929-018-0178-2 (2018).

    Article  Google Scholar 

  5. Stenflo, J., Fernlund, P., Egan, W. & Roepstorff, P. Proc. Natl Acad. Sci. USA 71, 2730–2733 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Patteson, J. B., Dunn, Z. D. & Li, B. Angew. Chem. Int. Ed. Engl. 57, 6780–6785 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gaudelli, N. M., Long, D. H. & Townsend, C. A. Nature 520, 383–387 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Haslinger, K., Peschke, M., Brieke, C., Maximowitsch, E. & Cryle, M. J. Nature 521, 105–109 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Max J. Cryle.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cryle, M.J. Pathway to malonic acid-containing metabolites. Nat Catal 1, 907–908 (2018). https://doi.org/10.1038/s41929-018-0191-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41929-018-0191-5

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing