A recent study performed directed C5-cytosine methylation of CpG islands to demonstrate that acquired methylation at critical loci could be reestablished for multiple generations in mice. This work provides a manipulatable system to examine how non-genetic information is transmitted across generations to regulate complex phenotypes.
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Sarkar, G., Greer, E.L. Inheritance of directed DNA cytosine methylation in mammals. Lab Anim 52, 105–107 (2023). https://doi.org/10.1038/s41684-023-01158-5
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DOI: https://doi.org/10.1038/s41684-023-01158-5
