Over the past 30 years, the field of structural biology and its associated biological insights have seen amazing progress. In this Comment, I recount several milestones in the field and how we can apply lessons from the past toward an exciting future, especially as it relates to drug discovery.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Frye, S. Nat. Chem. Biol. 6, 159–161 (2010).
Arrowsmith, C. et al. Nat. Chem. Biol. 11, 536–541 (2015).
Edwards, A. et al. Nature 470, 163–165 (2011).
Carter, A. J. et al. Drug Discov. Today 26, 607–612 (2019).
Jumper, J. et al. Nature 596, 583–589 (2021).
Baek, M. et al. Science 373, 871–876 (2021).
Kryshtafovych, A., Schwede, T., Topf, M., Fidelis, K. & Moult, J. Proteins 91, 1539–1549 (2020).
Nature 617, 438 (2023).
Ackloo, S. et al. Nat. Rev. Chem. 6, 287–295 (2022).
Acknowledgements
C.H.A. is funded by the Canadian Institutes for Health Research (FDN154328 and OGB190363), Canada foundation for Innovation, National Institutes of Health (U19 AI171292), Huntington Society of Canada, Princess Margaret Cancer Centre, The Princess Margaret Cancer Foundation, and Ontario Ministry of Health. The Structural Genomics Consortium is a registered charity (no. 1097737) that receives funds from Bayer AG, Boehringer Ingelheim, Bristol Myers Squibb, Genentech, Genome Canada through Ontario Genomics Institute (OGI-196), EU/EFPIA/OICR/McGill/KTH/Diamond Innovative Medicines Initiative 2 Joint Undertaking (EUbOPEN grant 875510), Janssen, Merck (known as EMD in Canada and the United States), Pfizer and Takeda.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Arrowsmith, C.H. Structure-guided drug discovery: back to the future. Nat Struct Mol Biol 31, 395–396 (2024). https://doi.org/10.1038/s41594-024-01244-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-024-01244-3