The modification of proteins with the small protein ubiquitin constitutes a Daedalian system of posttranslational modifications in every eukaryotic cell, which is often referred to as the ubiquitin code1. Here we consider the scale and complexity of the ubiquitin system in light of recent developments.
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Acknowledgements
B.C.L. and D.K. are supported by National Health and Medical Research Council Investigator grants GNT2016268 (B.C.L) and GNT1178122 (D.K.).
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D.K. is a co-founder, shareholder, and scientific advisory board member of Entact Bio.
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Lechtenberg, B.C., Komander, D. Just how big is the ubiquitin system?. Nat Struct Mol Biol 31, 210–213 (2024). https://doi.org/10.1038/s41594-023-01208-z
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DOI: https://doi.org/10.1038/s41594-023-01208-z