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Immunology

Multi-faceted immunoglobulin M meets its elusive receptor

Nature Structural & Molecular Biology volume 30, pages 866–869 (2023)Cite this article

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Immunoglobulin M (IgM) is the most ancient antibody class and key mediator of the primary immune response. New structures reveal how it binds to its only class-specific receptor (FcμR) and offer a tantalizing clue to the role of FcμR in the IgM B cell receptor.

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Fig. 1: Schematic representation of pentameric IgM.
Fig. 2: The two faces of the pIgM-Fc5 region.
Fig. 3: Modeling of FcμR interactions with IgM.

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Acknowledgements

B.J.S. is supported by the Medical Research Council (UK) (MR/V010557/1).

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  1. Randall Centre for Cell & Molecular Biophysics, King’s College London, London, UK

    Brian J. Sutton

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  1. Brian J. Sutton
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Correspondence to Brian J. Sutton.

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Sutton, B.J. Multi-faceted immunoglobulin M meets its elusive receptor. Nat Struct Mol Biol 30, 866–869 (2023). https://doi.org/10.1038/s41594-023-01030-7

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